In hydraulic fracturing applications, there is substantial interest to reduce the formation breakdown pressure. Previous research results show that the cyclic injection method can be used to reduce that pressure. In this study, we conducted laboratory hydraulic fracturing experiments to apply cyclic injection to reduce the breakdown pressures of very tight and strong sandstones. Experimental results show that using cyclic injection the average breakdown pressure was reduced by 18.9% in very tight sandstones and by 7.18% in normal sandstones. This indicates that the effect of cyclic injection is more significant for stronger and tighter rocks. The experiments also reveal that the rock tensile strength plays a more important role in the formation breakdown pressure with a rock strength factor of 2.85. This suggests that the breakdown pressure is higher than expected. In addition, we empirically related the breakdown pressure reduction and the injection pressure amplitude to the number of injection cycles. The curve fitting results imply that the effect of cyclic injection is more important if the number of cycles or the injection pressure amplitude is increased. Based on the results of this research, the in-situ formation breakdown pressure can be reduced by applying the cyclic injection method, and the breakdown pressure reduction is more significant as the number of cycles increases.