The loss of ozone to terrestrial and aquatic systems, known as dry deposition, is a highly uncertain process governed by turbulent transport, interfacial chemistry, and plant physiology. We demonstrate the value of using Deep Neural Networks (DNN) in predicting ozone dry deposition velocities. We find that a feedforward DNN trained on observations from a coniferous forest site (Hyytiälä, Finland) can predict hourly ozone dry deposition velocities at a mixed forest site (Harvard Forest, Massachusetts) more accurately than modern theoretical models, with a reduction in the normalized mean bias (0.05 versus ~0.1). The same DNN model, when driven by assimilated meteorology at 2° × 2.5° spatial resolution, outperforms the Wesely scheme as implemented in the GEOS-Chem model. With more available training data from other climate and ecological zones, this methodology could yield a generalizable DNN suitable for global models.