A method, apparatus, and program product utilize global sensitivity analysis (GSA) based on variance decomposition to calculate and apportion the contributions to a total variance of a measurement signal from uncertain input parameters of a subsurface model in connection with designing targeted surveys. Through the use of global sensitivity analysis in this manner, the geometry for a survey may be determined based on a desired target of the design, e.g., based on spatial properties (e.g., reservoir zone of interest) and/or physical properties (e.g., porosity, fluid density, rock physics properties) to select locations (e.g., source-receiver pairs) with greater uncertainty contributions from parameter group(s) of interest.